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Signatures calculation procedure #81
Description
Hello!
Thank you for the great resource!
I have tried to, but didn't manage to find the procedure for calculating scores—those in the section "Computed Signatures for CycleGAN Predicted RNA-Seq-Like Profiles of L1000 Samples (Level 5)." As I understand, it uses the "Characteristic Direction" method. For my project, I need fold changes along with p-values for reconstructed RNA-seq data. Especially, I am interested in how to match experimental samples and controls to produce case-control groups. Is this code present somewhere?
Activity
AviMaayan commentedon Feb 24, 2024
Hi @aurbn,
You can find more information about the procedure in this paper: https://bmcbioinformatics.biomedcentral.com/articles/10.1186/s12859-022-04895-5
The code is available from this repo:
https://github.com/MaayanLab/L1000toRNAseq
Best,
Avi