diff --git a/waterbutler/providers/s3/provider.py b/waterbutler/providers/s3/provider.py
index d86d9122e..587a59090 100644
--- a/waterbutler/providers/s3/provider.py
+++ b/waterbutler/providers/s3/provider.py
@@ -86,7 +86,7 @@ def __init__(self, auth, credentials, settings, **kwargs):
                 credentials['secret_key'], calling_format=OrdinaryCallingFormat())
         self.bucket = self.connection.get_bucket(settings['bucket'], validate=False)
         self.encrypt_uploads = self.settings.get('encrypt_uploads', False)
-        self.region = None
+        self.region = self.settings.get('region', None)
 
     async def validate_v1_path(self, path, **kwargs):
         await self._check_region()
@@ -851,10 +851,10 @@ async def _check_region(self):
             if self.region == 'EU':
                 self.region = 'eu-west-1'
 
-            if self.region != '':
-                self.connection.host = self.connection.host.replace('s3.', 's3-' + self.region + '.', 1)
-                self.connection._auth_handler = get_auth_handler(
-                    self.connection.host, boto_config, self.connection.provider, self.connection._required_auth_capability())
+        if self.region != '':
+            self.connection.host = self.connection.host.replace('s3.', 's3-' + self.region + '.', 1)
+            self.connection._auth_handler = get_auth_handler(
+                self.connection.host, boto_config, self.connection.provider, self.connection._required_auth_capability())
 
         self.metrics.add('region', self.region)